There's tons of stuff out there about how natal Saturn represents your fears. Your big "No". But let's look at the positive side.
The house that Saturn occupies in your chart is the area of your life where you (should) know how to set boundaries. Forget about the garbage that holds you back for a second, and just focus on how/where you set boundaries. Saturn implies limits. So, if you have Saturn in your 4th House (home and family) it should feel natural to set protective boundaries around your home (your personal, sacred space). Saturn in the 7th House...relationship boundaries. You know who you want. Don't worry about who you're not getting (or how alone you feel). You know exactly what you want in a relationship.
Saturn manifests. It crystallizes and makes things real. It's your best bet for really getting what you want. The key is pushing past the fear/isolation/depression (that Saturn can bring) and get down to its root; it helps you focus, it helps you set boundaries, it cuts out the excess.
It's the knife in your chart.